Immunological Deficits in Whipple´s Disease

Macrophages                  Impaired phagocytosis
 / Monocytes                  Impaired degradation
                                        Reduced Complement Receptor 3 (CD11b)
                                        Reduced Interleukin-12

T-Lymphocytes               Cutaneous anergy to recall antigens
                                        Reduced  proliferation

B-Lymphocytes               Hypogammaglobulinemia

Others                             Inhibitory serum factor

References:

1. 

2. Marth T, Roux M, von Herbay A, Meuer SC, Feurle GE (1994). Persistent reduction of complement receptor 3 alpha-chain expressing mononuclear cells and transient inhibitory factors in Whipple´s disease. Clin Immunol Immunopathol 72: 217--226

3.

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