Making the diagnosis
Whenever the suspicion arises that a patient may suffer from Whipple´s disease, the best way to check this possibility is a histologic study of small intestinal biopsies. For
this purpose, at least five mucosal biopsy particles should be obtained from the most distal part of the duodenum which can be reached with the endoscope:
- when intestinal histology is reported as normal, Whipple´s disease can bona fide be ruled out. There are only very few exceptions to this rule.
- in the case that intestinal histology is characteristic, or
at least suspicious of Whipple´s disease additional studies should be performed until confirmation is reached (PCR, electron microscopy).
To find more information about the histopathology
of intestinal Whipple´s disease, click to the buttom.
For information about
PCR analysis of intestinal biopsies, click the buttom.